Macrophage ageing is triggered by cancer stem cells: Study

Researchers at Hokkaido University have discovered that cancer stem cells cause immune cells called macrophages to undergo senescence, leading to tumor growth. The team found that cancer stem cells produced a molecule called interleukin 6 (IL-6) that triggered this effect. They also found that supplementing mice with a molecule called nicotinamide mononucleotide prevented tumor growth and increased survival times by promoting the proliferation of non-senescent macrophages.