Nobel Prize 2025: Three scientists share Physiology or Medicine award; honored for discoveries on peripheral immune tolerance

Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their discoveries concerning peripheral immune tolerance. Their work identified regulatory T cells, crucial for regulating the immune system and preventing autoimmune diseases. This groundbreaking research reshaped immunology, opening new avenues for treating autoimmune conditions and advancing cancer therapies.